FOR PROMETHEUS® Anser™ IFX (Test and Patient Information) CPT CODES as applied by Prometheus* PROMETHEUS® Anser™ IFX 84999 (x1) Unlisted Chemistry Procedure (Quantitative assay that measures serum infliximab (IFX) and antibodies to infliximab (ATI) concentrations *Facilities Description Prometheus is located in San Diego, CA.
08/25/17: Changed name from Measurement of Serum Antibodies to Infliximab and Adalimumab to Measurement of Serum Antibodies to Infliximab, Adalimumab, & Vedolizumab. Added testing for the measurement of antibodies to vedolizumab (e.g., Prometheus® Anser™ VDZ) as non-covered for all product lines. Policy reviewed and revised
Can also be used with IFX biosimilars. to vedolizumab (ATV) levels in serum. PROMETHEUS® Anser® UST - #3190 Simultaneously measures ustekinumab (UST) and antibodies to ustekinumab (ATU) levels in serum. PROMETHEUS® Anser® IFX - #3150 Simultaneously measures infliximab (IFX) and antibodies to infliximab (ATI) levels PLEASE PROVIDE ALL REQUIRED BILLING INFORMATION FOR EACH TEST PROMETHEUS Anser IFX and PROMETHEUS Anser ADA Zitomersky N, Chi L, Liu E, et al. Low infliximab levels and anti-infliximab antibodies increase the risk of loss of response to infliximab in pediatric IBD, a prospective pediatric study. Gastroenterology. 2018;154 (6 suppl 1):S-60.
The HACA portion of the test detects human anti-chimeric antibodies (HACA / antibodies to infliximab). Patients that develop HACA may experience infusion reactions and/or a reduced duration of efficacy of infliximab. The PROMETHEUS Anser IFX test is a new generation and more sensitive quantitative infliximab monitoring assay that allows healthcare providers to measure and monitor serum IFX and ATI levels anytime during therapy. Incorporating drug Simultaneously measures infliximab (IFX) and antibodies to infliximab (ATI) levels in serum at any time during therapy. Can also be used with IFX biosimilars. PROMETHEUS SERUM INFLIXIMAB/HACA MEASUREMENT Test ID: FPHAC Secondary ID: 91563 EXPLANATION OF CHANGE: Notification has been received from Prometheus Laboratories, Inc., effective August 17, 2012, Test ID FPHAC, will no longer be offered.
2016-01-22
assay for the measurement of infliximab and antibodies-to-infliximab levels in patient serum. J Immunol Methods.
1 Jan 2019 Prometheus has assessments for four biologics (adalimumab, infliximab, ustekinumab, and vedolizumab), which also measure the levels of
Standardization of the homogeneous mobility shift assay protocol for evaluation of anti-infliximab antibodies. Serum infliximab and ATI were measured using a commercially available homogenous mobility shift assay (Prometheus Laboratories Inc., San Diego, CA, USA). 10 The lower limit for detection of ATI in this assay was 3.13 U/mL. 11 We measured trough concentrations of infliximab, antibodies to microbial antigens, and circulating inflammatory markers in serum samples collected before treatment and at the time of infliximab discontinuation.
11. Study objectives. PROMETHEUS® Anser® IFX measures both serum infliximab levels and antibodies to infliximab – valuable information to help guide your treatment decisions for patients who lose response to infliximab. PROMETHEUS Serum Infliximab/HACA. Measurement can aid physicians in determining the dose of infliximab and guide infusion intervals. The HACA portion of the test detects human anti-chimeric antibodies (HACA / antibodies to infliximab). Patients that develop HACA may experience infusion reactions and/or a reduced duration of efficacy of infliximab.
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19. (22%) patienter ELISA, Prometheus Laboratories, CA enligt tidigare beskrivna metoder. >90%) increased bile acid synthesis as measured by serum C4 (7alpha-. Increased serum levels of cartilage oligomeric matrix protein precede the The cost-effectiveness of infliximab in the treatment of ankylosing spondylitis in Spain. and Morality- Is Kokoschka's The Prometheus Triptych a "good" work of art?
Incorporating drug monitoring may clarify what factors are contributing to a
PROMETHEUS® Anser™ tests uniquely provide both serum drug and antibody levels any time during treatment, offering critical data that may help you optimize patient clinical response. For IBD patients on infliximab or adalimumab Anser™ helps you take biologics further. The Prometheus Anser ® tests are quantitative monitoring assays that allow healthcare providers to measure and monitor both the levels of drug and anti-drug antibodies at anytime during therapy.
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Infliximab Level and Anti-drug Antibody for IBD - When treatment of inflammatory bowel disease with infliximab or its biosimilar fails, a physician may need to consider treatment options, such as adjusting dose or dosing intervals, switching to a different TNF blocker, or switching to a non-TNF blocker.
Measurement can aid physicians in determining the dose of infliximab and guide infusion intervals. The HACA portion of the test detects human anti-chimeric antibodies (HACA / antibodies to infliximab). Patients that develop HACA may experience infusion reactions and/or a reduced duration of efficacy of infliximab.
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In the presence of anti-infliximab antibodies, the infliximab drug level typically reflects the antibody-unbound fraction of infliximab concentration in serum. The presence of infliximab drug, even at concentrations well above target treatment levels (>50 μg/mL), does not interfere with the anti-infliximab antibody detection.
Infliximab Level and Anti-drug Antibody for IBD - When treatment of inflammatory bowel disease with infliximab or its biosimilar fails, a physician may need to consider treatment options, such as adjusting dose or dosing intervals, switching to a different TNF blocker, or switching to a non-TNF blocker. Each serum sample was assessed for infliximab and antibodies against infliximab in duplicate in a blinded fashion by Prometheus Laboratories; the values reported are the means. Fifty IBD patients completing IFX induction were monitored during maintenance (weeks 14-54). Clinical and laboratory data were collected at each infusion; serum was analyzed for IFX concentrations and anti-drug antibodies (ADA) at weeks 14 and 54 (Prometheus Labs, San Diego). Dosing was blinded to PK data. 08/25/17: Changed name from Measurement of Serum Antibodies to Infliximab and Adalimumab to Measurement of Serum Antibodies to Infliximab, Adalimumab, & Vedolizumab.